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      On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging.

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          Abstract

          The identification of alternative biocompatible magnetic NPs for advanced clinical application is becoming an important need due to raising concerns about iron accumulation in soft issues associated to the administration of superparamagnetic iron oxide nanoparticles (NPs). Here, we report on the performance of previously synthetized iron-doped hydroxyapatite (FeHA) NPs as contrast agent for magnetic resonance imaging (MRI). The MRI contrast abilities of FeHA and Endorem® (dextran coated iron oxide NPs) were assessed by 1H nuclear magnetic resonance relaxometry and their performance in healthy mice was monitored by a 7 Tesla scanner. FeHA applied a higher contrast enhancement, and had a longer endurance in the liver with respect to Endorem® at iron equality. Additionally, a proof of concept of FeHA use as scintigraphy imaging agent for positron emission tomography (PET) and single photon emission computed tomography (SPECT) was given labeling FeHA with 99mTc-MDP by a straightforward surface functionalization process. Scintigraphy/x-ray fused imaging and ex vivo studies confirmed its dominant accumulation in the liver, and secondarily in other organs of the mononuclear phagocyte system. FeHA efficiency as MRI-T2 and PET-SPECT imaging agent combined to its already reported intrinsic biocompatibility qualifies it as a promising material for innovative nanomedical applications.

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          Author and article information

          Journal
          Acta Biomater
          Acta biomaterialia
          Elsevier BV
          1878-7568
          1742-7061
          Jun 2018
          : 73
          Affiliations
          [1 ] Institute of Science and Technology for Ceramics (ISTEC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, Italy. Electronic address: alessio.adamiano@istec.cnr.it.
          [2 ] Institute of Science and Technology for Ceramics (ISTEC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, Italy.
          [3 ] Physics Department and INSTM, Università degli Studi di Milano, Via Celoria 16, 20133 Milano, Italy.
          [4 ] Preclinical Imaging Facility Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy.
          [5 ] Experimental Hepatology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy.
          [6 ] Preclinical Imaging Facility Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy; Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milan, Italy; Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
          [7 ] CNR-SPIN and Department of Physics "E. Pancini", University of Naples "Federico II", Piazzale V. Tecchio 80, I-80125 Napoli, Italy.
          [8 ] Institute of Nuclear & Radiological Sciences, Technology, Energy & Safety, NCSR "Demokritos", Ag. Paraskevi 153-10, Athens, Greece.
          [9 ] Bioemission Technology Solutions, Alexandras 116, Athens, Greece.
          [10 ] Institute of Nuclear & Radiological Sciences, Technology, Energy & Safety, NCSR "Demokritos", Ag. Paraskevi 153-10, Athens, Greece; Bioemission Technology Solutions, Alexandras 116, Athens, Greece.
          [11 ] Physics Department and INSTM, Università degli Studi di Milano, Via Celoria 16, 20133 Milano, Italy; Istituto di Nano Scienze, CNR-S3, Via Campi 213/A, 41125 Modena, Italy.
          Article
          S1742-7061(18)30243-5
          10.1016/j.actbio.2018.04.040
          29689381
          1b0aa443-6630-4915-aae3-c48a1d884a7e
          History

          Liver imaging,Magnetic hydroxyapatite nanoparticles,SPECT/MRI

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