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      Protective effects of isoatriplicolide tiglate from Paulownia coreana against glutamate-induced neurotoxicity in primary cultured rat cortical cells.

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          Abstract

          To examine the neuroprotective effects of Paulownia coreana, we tested its protection against the glutamate-induced neurotoxicity to primary cultured cortical neurons. An aqueous extract of the plants exhibited significant protection against glutamate-induced toxicity in primary cultured rat cortical cells. In order to clarify the neuroprotective mechanism(s) of this observed effect, isolation was performed to seek and identify active fractions and components. By such fractionation, one bioactive sesquiterpene lactone, isoatriplicolide tiglate, was isolated, which exhibited significant neuroprotective activities against glutamate-induced toxicity, exhibiting cell viability of about 50%, at concentrations ranging from 0.1 microM to 10 microM.

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          Author and article information

          Journal
          Nat Prod Commun
          Natural product communications
          1934-578X
          1555-9475
          Jun 2010
          : 5
          : 6
          Affiliations
          [1 ] Department of Applied Life Science, Kon Kuk University, Seoul 143-701, South Korea.
          Article
          20614807
          1b5c4221-e07c-4fb7-b35a-4d1d4308a658
          History

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