The evidence that breastfeeding improves cognitive development is based almost entirely
on observational studies and is thus prone to confounding by subtle behavioral differences
in the breastfeeding mother's behavior or her interaction with the infant.
To assess whether prolonged and exclusive breastfeeding improves children's cognitive
ability at age 6.5 years.
Cluster-randomized trial, with enrollment from June 17, 1996, to December 31, 1997,
and follow-up from December 21, 2002, to April 27, 2005.
Thirty-one Belarussian maternity hospitals and their affiliated polyclinics.
A total of 17,046 healthy breastfeeding infants were enrolled, of whom 13,889 (81.5%)
were followed up at age 6.5 years.
Breastfeeding promotion intervention modeled on the Baby-Friendly Hospital Initiative
by the World Health Organization and UNICEF.
Subtest and IQ scores on the Wechsler Abbreviated Scales of Intelligence, and teacher
evaluations of academic performance in reading, writing, mathematics, and other subjects.
The experimental intervention led to a large increase in exclusive breastfeeding at
age 3 months (43.3% for the experimental group vs 6.4% for the control group; P <
.001) and a significantly higher prevalence of any breastfeeding at all ages up to
and including 12 months. The experimental group had higher means on all of the Wechsler
Abbreviated Scales of Intelligence measures, with cluster-adjusted mean differences
(95% confidence intervals) of +7.5 (+0.8 to +14.3) for verbal IQ, +2.9 (-3.3 to +9.1)
for performance IQ, and +5.9 (-1.0 to +12.8) for full-scale IQ. Teachers' academic
ratings were significantly higher in the experimental group for both reading and writing.
These results, based on the largest randomized trial ever conducted in the area of
human lactation, provide strong evidence that prolonged and exclusive breastfeeding
improves children's cognitive development.
isrctn.org Identifier: ISRCTN37687716.