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Antibody responses to SARS-CoV-2 in patients with COVID-19
Quan-Xin Long ,
Bai-Zhong Liu ,
Hai-Jun Deng ,
Gui-Cheng Wu ,
Kun Deng ,
Yao-Kai Chen ,
Pu Liao ,
Jing-Fu Qiu ,
Yong Lin ,
Xue-Fei Cai ,
De-Qiang Wang ,
Yuan Hu ,
Ji-Hua Ren ,
Ni Tang ,
Yin-Yin Xu ,
Li-Hua Yu ,
Zhan Mo ,
Fang Gong ,
Xiao-Li Zhang ,
Wen-Guang Tian ,
Li Hu ,
Xian-Xiang Zhang ,
Jiang-Lin Xiang ,
Hong-Xin Du ,
Hua-Wen Liu ,
Chun-Hui Lang ,
Xiao-He Luo ,
Shao-Bo Wu ,
Xiao-Ping Cui ,
Zheng Zhou ,
Man-Man Zhu ,
Jing Wang ,
Cheng-Jun Xue ,
Xiao-Feng Li ,
Li Wang ,
Zhi-Jie Li ,
Kun Wang ,
Chang-Chun Niu ,
Qing-Jun Yang ,
Xiao-Jun Tang ,
Yong Zhang ,
Xia-Mao Liu ,
Jin-Jing Li ,
De-Chun Zhang ,
Fan Zhang ,
Ping Liu ,
Jun Yuan ,
Qin Li ,
Jie-Li Hu ,
Juan Chen ,
Ai-Long Huang
April 29 2020
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Abstract
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within
19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G
(IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both
IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing
may be helpful for the diagnosis of suspected patients with negative RT-PCR results
and for the identification of asymptomatic infections.