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      Rat coronavirus (RCV): A prevalent, naturally occurring pneumotropic virus of rats

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          Summary

          A new virus isolated from the lungs of rats is prevalent in colony reared and wild rats and induces a fatal pneumonitis in newborn rats. The virus, designated as rat coronavirus (RCV), exhibits properties representative of the coronavirus group: characteristic surface structure, particles somewhat variable in size averaging approximately 90 mμ, apparent RNA content, essential lipid, heat sensitivity, and a close serologie relationship with the mouse hepatitis virus complex. RCV grows well in primary rat kidney cell cultures, exhibits a pathognomonic type CPE, and produces a complement fixing antigen which is sensitive for detection of antibody and useful in sero-epidemiologic studies.

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          Most cited references16

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          Morphogenesis of avian infectious bronchitis virus and a related human virus (strain 229E).

          Avian infectious bronchitis virus (IBV) and strain 229E, a virus recently recovered from patients with colds, have been shown to possess a similar distinctive morphology in negatively stained preparations. An electron microscopic study of the morphogenesis of IBV in the chorioallantoic membrane and of strain 229E in WI-38 cells was performed. In infected cells, round electron-dense particles 82 mmu in diameter were observed to form by a process of budding from membranes of the endoplasmic reticulum and cytoplasmic vesicles. The particles in IBV-infected cells were similar in size and shape to those in strain 229E-infected cells but showed certain differences in internal structure. The evidence that the particles represent virions and the implications of these findings in the classification of this virus group are discussed.
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            Isolation from Man of “Avian Infectious Bronchitis Virus-like” Viruses (Coronaviruses * ) similar to 229E Virus, with Some Epidemiological Observations

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              Antigenic relationships among the coronaviruses of man and between human and animal coronaviruses.

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                Author and article information

                Journal
                Arch Gesamte Virusforsch
                Arch Gesamte Virusforsch
                Archiv Fur Die Gesamte Virusforschung
                Springer-Verlag (Vienna )
                0003-9012
                1432-8798
                1970
                : 31
                : 3
                : 293-302
                Affiliations
                [1 ]GRID grid.419803.7, Microbiological Associates, Inc., ; Bethesda, Maryland USA
                [2 ]GRID grid.419681.3, ISNI 0000000121649667, Laboratory of Viral Diseases, , National Institute of Allergy and Infectious Diseases National Institutes of Health, ; Bethesda, Md. USA
                Article
                BF01253764
                10.1007/BF01253764
                7086756
                4099196
                1b93ba9f-f167-462f-89c2-26ccbe4ca459
                © Springer-Verlag 1970

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                : 8 January 1970
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                Custom metadata
                © Springer-Verlag 1970

                hepatitis,property representative,heat sensitivity,mouse hepatitis virus,virus complex

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