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      Polydiscamides B-D from a marine sponge Ircinia sp. as potent human sensory neuron-specific G protein coupled receptor agonists.

      Journal of Natural Products

      agonists, Animals, Receptors, G-Protein-Coupled, chemistry, Porifera, pharmacology, isolation & purification, Peptides, Cyclic, drug effects, Pain Measurement, Neurons, Afferent, Molecular Structure, Humans, Australia

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          Abstract

          Polydiscamides B, C, and D (1-3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.

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          Journal
          10.1021/np070094r
          18163586

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