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An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro.
M Aikawa
1 ,
E Rabkin ,
S Sugiyama ,
S J Voglic ,
Y Fukumoto ,
Y Furukawa ,
M Shiomi ,
F J Schoen ,
P Libby
Jan 16 2001
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Abstract
Unstable atherosclerotic plaques that cause acute coronary events usually contain abundant macrophages expressing matrix metalloproteinases (MMPs) and tissue factor (TF), molecules that probably contribute to plaque rupture and subsequent thrombus formation. Lipid lowering with HMG-CoA reductase inhibitors reduces acute coronary events.