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      Effect of Lathyrogens on Glycosaminoglycans of Bovine Cornea in vitro

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          Bovine corneas were incubated in vitro with various lathyrogens in a medium containing radioactive sulphate. The effect of lathyrogens resulted in the decrease of the content of ester sulphate radioactivity in the corneal matter proportional to the concentration of lathyrogens in the incubation medium. Isolated glycosaminoglycans showed lower specific radioactivity after the action of lathyrogens on the cornea. By means of cetylpyridinium chloride-cellulose fractionation technique, it was found that preferential sulphation of galactosaminoglycans was inhibited whereas sulphation of glucosaminoglycans did not reveal any change. Tensile strength of corneal strips incubated in vitro in the presence of lathyrogens as well as the total collagen content in the corneal dry weight were not influenced by the action of lathyrogens.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          27 November 2009
          : 1
          : 4
          : 220-227
          Laboratory of Physiology and Pathology of the Eye, Czechoslovak Academy of Sciences, Prague
          264520 Ophthal Res 1970;1:220–227
          © 1970 S. Karger AG, Basel

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          Pages: 8


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