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      Dissecting corollary discharge dysfunction in schizophrenia.

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          Abstract

          During talking, a corollary discharge prepares cortex for self-generated sounds, minimizing responsiveness and providing a way to recognize sounds as self-generated. When we talk, we are the agent producing the sound and know what sound to expect. The auditory ERP N1 is normally suppressed during talking, but less so in schizophrenia, perhaps due to deficits in agency and expectancy inherent to talking. N1 was assessed in 27 patients (23 schizophrenia, 4 schizoaffective) and 26 controls. During talking, subjects said "ah" every 1-2 s. During agency, subjects pressed a button to deliver "ah" every 1-2 s. During expectancy, "ah" followed a visual warning. Talking yielded greatest N1 suppression in controls and greatest suppression failure in patients. Agency and expectancy had modest suppression effects on N1 and only in controls. Group differences in expectancy and agency could not account for failed corollary discharge during talking in patients.

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          Author and article information

          Journal
          Psychophysiology
          Psychophysiology
          Wiley
          0048-5772
          0048-5772
          Jul 2007
          : 44
          : 4
          Affiliations
          [1 ] Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven 06517, and Department of Psychiatry, Yale University School of Medicne, New Haven, Connecticut, USA. Judith.ford@yale.edu
          Article
          PSYP533
          10.1111/j.1469-8986.2007.00533.x
          17565658
          1bb85c09-5d70-4412-944d-6544aa1b623c
          History

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