10
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Effects of fluoride on synaptic membrane fluidity and PSD-95 expression level in rat hippocampus.

      1 , ,
      Biological trace element research
      Springer Nature

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The objective of this study is to investigate the neurotoxicity of drinking water fluorosis on rat hippocampus. Just weaning male Sprague-Dawley rats were randomly divided into four groups and given 15, 30, and 60 mg/L NaF solution and distilled water, respectively, for 9 months. The fluidity of brain synaptic membrane and expression level of postsynaptic density 95 (PSD-95) were tested. Results showed that the fluidity of brain synaptic membrane decreased gradually with increasing of fluoride concentration, and it was significantly decreased (P < 0.05) in moderate-fluoride group compared with control group, and expression level of PSD-95 was significantly decreased (P < 0.01) in moderate-fluoride group when compared with that of control group. These results indicate that decrease of synaptic membrane fluidity and PSD-95 expression level may be the molecular basis of central nervous system damage caused by fluoride intoxication; PSD-95 in CA3 region of hippocampus is probably a target molecule for fluoride.

          Related collections

          Author and article information

          Journal
          Biol Trace Elem Res
          Biological trace element research
          Springer Nature
          1559-0720
          0163-4984
          Feb 2011
          : 139
          : 2
          Affiliations
          [1 ] Institute of Ecology, Zhejiang Normal University, Jinhua 321004, People's Republic of China.
          Article
          10.1007/s12011-010-8654-9
          20217272
          1bc20af7-9bcc-4c19-b2a7-f1953d9d0005
          History

          Comments

          Comment on this article