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      Chronic inflammation in the etiology of disease across the life span

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          Abstract

          Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.

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          Journal
          Nature Medicine
          Nat Med
          Springer Science and Business Media LLC
          1078-8956
          1546-170X
          December 2019
          December 05 2019
          December 2019
          : 25
          : 12
          : 1822-1832
          Article
          10.1038/s41591-019-0675-0
          7147972
          31806905
          1bc26312-90fe-4823-b5dc-5310a351badd
          © 2019

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          http://www.springer.com/tdm

          http://www.springer.com/tdm

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