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      Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.

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      Clinical therapeutics

      Elsevier BV

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          Abstract

          Parallel with the development of hypotheses regarding cholinergic involvement in geriatric memory dysfunction, the first attempts to treat patients with Alzheimer's disease (AD) involved the cholinergic-precursor loading approach. Despite encouraging early results, well-controlled clinical trials did not confirm a clinical utility of cholinergic precursors such as choline and lecithin (phosphatidylcholine) in AD.

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          Author and article information

          Journal
          Clin Ther
          Clinical therapeutics
          Elsevier BV
          0149-2918
          0149-2918
          Jan 2003
          : 25
          : 1
          Affiliations
          [1 ] Instituto Nacional de la Senectud, Mexico City, Mexico.
          Article
          S0149291803900233
          10.1016/s0149-2918(03)90023-3
          12637119

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