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      Alcohol misuse requiring admission to a tertiary referral ICU: resource implications

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      1 , 1 , 1
      Critical Care
      BioMed Central
      29th International Symposium on Intensive Care and Emergency Medicine
      24-27 March 2009

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          Abstract

          Introduction Alcohol misuse is associated with many conditions requiring ICU management [1]. In 2006/2007, 1.53% of all hospital admissions were related to alcohol misuse (regional audit). We conducted a prospective audit in a tertiary referral adult ICU to ascertain the proportion of ICU capacity used for the treatment of conditions related to alcohol misuse. Methods Patients admitted to a tertiary referral ICU between 1 November 2006 and 31 March 2007 were prospectively audited with the aim of identifying all cases in which the reason for admission could be attributed to acute or chronic alcohol misuse. Blood alcohol levels, past history from the patient/relatives or previous relevant clinical investigations and/or diagnoses were reviewed for evidence of acute or chronic alcohol misuse. Results Of 318 ICU admissions during the audit, 9.43% (30 admissions – 20 male/10 female) were judged to be due to either acute (19 of 30) or chronic (11 of 30) alcohol consumption. The mean patient age was 48.7 years (SD 14.1, range 25 to 74). Blood alcohol level on admission to hospital was available in 13 patients (43%), the median value being 170 mg% (IQR = 66 to 274). Seventeen patients (56.6%) were admitted following trauma, of whom 10 (33.3%), had brain injuries. The median length of stay (LOS) in the ICU was 10 days (IQR = 4 to 15) and the median LOS in hospital was 22 days (IQR = 10 to 38). The ICU mortality rate was 23.3% (seven out of 30) and hospital mortality was 30% (nine out of 30). During the audit period, a total of 2,567 ICU bed-days were available, of which 357 bed-days (13.9%) were used to treat this group of patients. The mean ICU occupancy during this period was 95.6%. Conclusion Alcohol misuse was implicated in almost 10% of ICU admissions – over six times the equivalent rate for total hospital admissions. These admissions required approximately 14% of total ICU capacity at a time when occupancy was almost 100%. Intensive care is a finite and expensive hospital resource. Public health bodies should be informed of the proportion of that resource required to treat alcohol-related illness and injury.

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          Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients.

          To determine the association between alcohol dependence (alcoholism not in remission and/or alcohol withdrawal) and sepsis, septic shock, and hospital mortality among intensive care unit (ICU) patients. Retrospective cohort study. Two ICUs in an urban hospital. Patients included 11,651 adult admissions to Denver Health Medical Center from January 1, 1999, to December 31, 2004, with >or=1 ICU day. None. Of first admissions appearing in the data set (n=9,981), 1,222 (12.2%) had a diagnosis consistent with alcohol dependence. These patients had higher rates of sepsis (12.9% vs. 7.6%, p<.001), organ failure (67.3% vs. 45.8%, p<.001), septic shock (3.6% vs. 2.1%, p=.001), and hospital mortality (9.4% vs. 7.5%, p=.022) on unadjusted analyses. Patients with alcohol dependence also had fewer hospital-free days. After adjustment for factors with known association with sepsis, alcohol dependence was associated with sepsis. This association was modified if the patient received (adjusted odds ratio, 0.92; 95% confidence interval, 0.65-1.31) or did not receive (adjusted odds ratio, 1.91; 95% confidence interval, 1.49-2.44) red cell transfusions. A general predisposition to infections mediated some, but not all, of this association. Results were similar when repeat admissions were included in the analysis. Alcohol dependence was also associated with septic shock and hospital mortality in multivariable analyses. Among those with liver disease and sepsis, alcohol dependence was associated with more than two-fold increased risk-adjusted odds of hospital mortality (adjusted odds ration, 2.31; 95% confidence interval, 1.26-4.24). Similarly, sepsis and liver disease carried higher odds of death for alcohol-dependent patients than for those without alcohol dependence. Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among ICU patients. The underlying mechanisms of this association require exploration, as an increased rate of infections mediated some, but not all, of this association.
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            Author and article information

            Conference
            Crit Care
            Crit Care
            Critical Care
            BioMed Central
            1364-8535
            1466-609X
            2009
            13 March 2009
            : 13
            : Suppl 1
            : P461
            Affiliations
            [1 ]Belfast HSC Trust & Faculty of Life and Health Sciences, University of Ulster, Belfast, UK
            Article
            cc7625
            10.1186/cc7625
            4084347
            1bcccd49-51c2-444e-a81f-7e02ee2d7cdb
            Copyright © 2009 Trainor et al; licensee BioMed Central Ltd.
            29th International Symposium on Intensive Care and Emergency Medicine
            Brussels, Belgium
            24-27 March 2009
            History
            Categories
            Poster Presentation

            Emergency medicine & Trauma
            Emergency medicine & Trauma

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