For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
23
views
59
references
 Top references
cited by
22
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      353
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The pathogenesis of neurological diseases and disorders remains mostly unknown. Neuroinflammation has been proposed as a causative factor for neurological diseases. The confirmation that neurogenesis occurs in the adult brain and neural stem cells (NSCs) reside in the adult central nervous system (CNS) of mammals has tremendous implications for our understanding of the physio- and pathology of the nervous system. The generation of newborn neuronal cells in the adult brain is modulated in neurological diseases and during inflammation. This suggests that adult neurogenesis is involved in the pathogenesis of neurological diseases and disorders, particularly during neuroinflammation. In this manuscript, we will review the modulation of adult neurogenesis in neurological diseases and during neuroinflammation. We will discuss the role and contribution of neuroinflammation and adult neurogenesis to neurological diseases and disorders, and for the therapeutic potential of adult NSCs.

          Related collections

          Most cited references59

          • Record: found
          • Abstract: found
          • Article: not found

          Neuronal replacement from endogenous precursors in the adult brain after stroke.

          Andreas Arvidsson, Tove Collin, Deniz Kirik … (2002)
          In the adult brain, new neurons are continuously generated in the subventricular zone and dentate gyrus, but it is unknown whether these neurons can replace those lost following damage or disease. Here we show that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone. Stroke-generated new neurons, as well as neuroblasts probably already formed before the insult, migrate into the severely damaged area of the striatum, where they express markers of developing and mature, striatal medium-sized spiny neurons. Thus, stroke induces differentiation of new neurons into the phenotype of most of the neurons destroyed by the ischemic lesion. Here we show that the adult brain has the capacity for self-repair after insults causing extensive neuronal death. If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans.
          Article 0 comments Cited 609 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus.

            Eric J. Nestler, J Malberg, Amelia J. Eisch … (2000)
            Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may contribute to the pathophysiology of depression. The aim of this study was to investigate the effect of antidepressants on hippocampal neurogenesis in the adult rat, using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells. Our studies demonstrate that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus. Administration of several different classes of antidepressant, but not non-antidepressant, agents was found to increase BrdU-labeled cell number, indicating that this is a common and selective action of antidepressants. In addition, upregulation of the number of BrdU-labeled cells is observed after chronic, but not acute, treatment, consistent with the time course for the therapeutic action of antidepressants. Additional studies demonstrated that antidepressant treatment increases the proliferation of hippocampal cells and that these new cells mature and become neurons, as determined by triple labeling for BrdU and neuronal- or glial-specific markers. These findings raise the possibility that increased cell proliferation and increased neuronal number may be a mechanism by which antidepressant treatment overcomes the stress-induced atrophy and loss of hippocampal neurons and may contribute to the therapeutic actions of antidepressant treatment.
            Article 0 comments Cited 342 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice.

              T Bush, N Puvanachandra, C Horner … (1999)
              Reactive astrocytes adjacent to a forebrain stab injury were selectively ablated in adult mice expressing HSV-TK from the Gfap promoter by treatment with ganciclovir. Injured tissue that was depleted of GFAP-positive astrocytes exhibited (1) a prolonged 25-fold increase in infiltration of CD45-positive leukocytes, including ultrastructurally identified monocytes, macrophages, neutrophils, and lymphocytes, (2) failure of blood-brain barrier (BBB) repair, (3) substantial neuronal degeneration that could be attenuated by chronic glutamate receptor blockade, and (4) a pronounced increase in local neurite outgrowth. These findings show that genetic targeting can be used to ablate scar-forming astrocytes and demonstrate roles for astrocytes in regulating leukocyte trafficking, repairing the BBB, protecting neurons, and restricting nerve fiber growth after injury in the adult central nervous system.
              Article 0 comments Cited 263 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Med Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Medical Sciences
                Publisher: Ivyspring International Publisher (Sydney )
                ISSN (Electronic): 1449-1907
                Publication date Collection: 2008
                Publication date (Electronic): 5 June 2008
                Volume: 5
                Issue: 3
                Pages: 127-132
                Affiliations
                1. Fighting Blindness Vision Research Institute, National Institute for Cellular Biotechnology, Glasnevin. Dublin 9, Ireland.
                2. Dublin City University, Dublin 9, Ireland.
                Author notes
                Correspondence to: Philippe Taupin, Fighting Blindness Vision Research Institute. National Institute for Cellular Biotechnology. Dublin City University. Glasnevin. Dublin 9, Ireland. Email: philippe.taupin@ 123456dcu.ie

                Conflict of interest: The author has declared that no conflict of interest exists.

                Article
                Publisher ID: ijmsv05p0127
                DOI: 10.7150/ijms.5.127
                PMC ID: 2424180
                PubMed ID: 18566676
                SO-VID: 1bfa543b-ec93-460e-947d-44a06d95aff4
                Copyright © © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
                History
                Date received : 12 April 2008
                Date accepted : 4 June 2008
                Categories
                Subject: Review

                ScienceOpen disciplines: Medicine
                Keywords: neurogenesis,neural stem cells,neuroinflammation
                Data availability:
                ScienceOpen disciplines: Medicine
                Keywords: neurogenesis, neural stem cells, neuroinflammation

                Comments

                Comment on this article

                scite_

                Similar content353

                See all similar

                Cited by21

                See all cited by

                Most referenced authors1,191

                See all reference authors