Retrograde Coronary Sinus Perfusion Provides Non-Homogeneous Myocardial Blood Flow

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Abstract

The ability of retrograde cardioplegia to protect the right ventricle has been questioned. Canine myocardial circulation was assessed by infusing colored microspheres through the coronary sinus. The relative flow index (RFI), a normalized measure of tissue blood flow, was determined for 76 sections of myocardium. Three distinct flow regions were evident from these measurements. A paucity of blood flow through some basal sections of the right ventricle (RFI = 0.23 ± 0.19) was found to be significantly different (p < 0.005) from regions of the heart with normal flow (RFI = 1.12 ± 0.06). Sections from the right ventricular apex demonstrated augmented flow (RFI = 3.72 ± 1.18). These data indicate that retrograde coronary perfusion provides nonuniform flow and under some conditions may provide inadequate perfusion to portions of the right ventricle.

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Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1993

Publication date (Print): 1993

Publication date (Electronic): 18 November 2008

Volume: 83

Issue: 5-6

Pages: 331-338

Affiliations

Division of Cardiothoracic Surgery, Department of Surgery, University of Massachusetts Medical Center, Worchester, Mass., USA

Article

Publisher ID: 175989 Other ID: Cardiology 1993;83:331–338

DOI: 10.1159/000175989

PubMed ID: 8111766

SO-VID: 1c1cdd27-e1a8-4dba-a0c2-1f2c4ed02319

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 12 August 1993

Date accepted : 25 August 1993

Page count

Pages: 8

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