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      Therapeutic Potential of Natural Plant Products and their Metabolites in Preventing Radiation Enteropathy resulting from Abdominal or Pelvic Irradiation

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          Abstract

          Purpose:

          Radiation-induced gastrointestinal injury or radiation enteropathy is an imminent risk during radiation therapy of abdominal or pelvic tumors. Despite remarkable technological advancements in image-guided radiation delivery techniques, the risk of intestinal injury after radiotherapy for abdominal or pelvic cancers has not been completely eliminated. The irradiated intestine undergoes varying degrees of adverse structural and functional changes, which can result in transient or long-term complications. The risk of development of enteropathy depends on dose, fractionation and quality of radiation. Moreover, the patients’ medical condition, age, inter-individual sensitivity to radiation and size of the treatment area are also risk factors of radiation enteropathy. Therefore, strategies are needed to prevent radiotherapy-induced undesirable alteration in the gastrointestinal tract. Many natural plant products, by virtue of their plethora of biological activities, alleviate the adverse effects of radiation-induced injury. The current review discusses potential roles and possible mechanisms of natural plant products in suppressing radiation enteropathy.

          Conclusions:

          Natural plant products have the potential to suppress intestinal radiation toxicity.

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          Author and article information

          Journal
          8809243
          4885
          Int J Radiat Biol
          Int. J. Radiat. Biol.
          International journal of radiation biology
          0955-3002
          1362-3095
          10 February 2019
          08 January 2019
          April 2019
          01 April 2020
          : 95
          : 4
          : 493-505
          Affiliations
          [1 ] Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy
          [2 ] College of Medicine, Department of Pathology; University of Arkansas for Medical Sciences, Little Rock, AR, United States of America
          Author notes
          [* ] Corresponding author: Rupak Pathak, Ph.D, Division of Radiation Health, Department of Pharmaceutical Sciences, UAMS College of Pharmacy, Winthrop P. Rockefeller Cancer Institute, 4301 W. Markham St., Little Rock, AR 72205, (501) 603-1472 (Off), (501) 247-6350 (cell), rpathak@ 123456uams.edu
          Article
          PMC6461490 PMC6461490 6461490 nihpa1520411
          10.1080/09553002.2018.1552374
          6461490
          30526224
          Categories
          Article

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