10
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Zn-3Li Alloy after Extrusion and Drawing: Structural, Mechanical Characterization, and Biodegradation in Abdominal Aorta of Rat

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Zinc shows great promise as a bioabsorbable metal. Our early in vivo investigations implanting pure zinc wires into the abdominal aorta of Sprague-Dawley rats revealed that metallic zinc does not promote restenotic responses and may suppress the activities of inflammatory and smooth muscle cells. However, the low tensile strength of zinc remains a major concern.

          A cast billet of the Zn-Li alloy was produced in a vacuum induction caster under argon atmosphere, followed by a wire drawing process. Two phases of the binary alloy identified by x-ray diffraction include the zinc phase and intermetallic LiZn 4 phase. Mechanical testing proved that incorporating 3 at.% of Li into Zn increased its ultimate tensile strength from 116 ± 13 MPa (pure Zn) to 274 ± 61 MPa while the ductility was held at 17 ± 7%. Implantation of 10 mm Zn-3Li wire segments into abdominal aorta of rats revealed an excellent biocompatibility of this material in the arterial environment. The biodegradation rate for Zn-3Li was found to be about 0.008 mm/yr and 0.045 mm/yr at 2 and 12 months, respectively.

          Graphical abstract

          Related collections

          Author and article information

          Journal
          101484109
          38985
          Mater Sci Eng C Mater Biol Appl
          Mater Sci Eng C Mater Biol Appl
          Materials science & engineering. C, Materials for biological applications
          0928-4931
          1873-0191
          8 April 2017
          11 March 2017
          01 July 2017
          01 July 2018
          : 76
          : 301-312
          Affiliations
          [1 ]Department of Materials Science and Engineering, Michigan Technological University, Houghton, Michigan, USA
          [2 ]Department of Biomedical Engineering, Michigan Technological University, Houghton, Michigan, USA
          [3 ]Institut für Werkstoffkunde (Materials Science), Leibniz Universität Hannover, Garbsen, Germany
          Author notes
          [* ]Corresponding author: jwdrelic@ 123456mtu.edu (Jaroslaw W. Drelich)
          Article
          PMC5459357 PMC5459357 5459357 nihpa861078
          10.1016/j.msec.2017.02.167
          5459357
          28482531
          1c2094c0-fa45-4029-a284-618053d3de1c
          History
          Categories
          Article

          Comments

          Comment on this article