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      Estrogen receptor alpha gene polymorphisms and breast cancer risk.

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          Abstract

          We conducted a hospital-based case-control study to evaluate the association between the XbaI and PvuII restriction fragment length polymorphisms (RFLPs) in intron I of the estrogen receptor alpha (ER alpha) gene and breast cancer risk. The study population consisted of 205 histologically confirmed incident breast cancer cases and 205 age-matched controls with no present and previous history of cancer. The PvuII genotype distribution did not show any difference between cases and controls, but the adjusted odds ratio (OR) for the XbaI X allele containing genotypes was 0.4 (95% CI: 0.3-0.6) compared with the xx genotype. The decrease in the OR appeared to be more attributable to the postmenopausal women; the ORs were 0.3 (95% CI: 0.1-0.5) and 0.5 (95% CI: 0.3-0.9) for postmenopausal and premenopausal women, respectively. Our results therefore suggest that the ER alpha XbaI polymorphism modifies individual susceptibility to breast cancer in Korean women.

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          Author and article information

          Journal
          Breast Cancer Res Treat
          Breast cancer research and treatment
          Springer Science and Business Media LLC
          0167-6806
          0167-6806
          Jul 2003
          : 80
          : 1
          Affiliations
          [1 ] Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
          Article
          10.1023/a:1024439202528
          12889606
          1c39c645-84a8-4ede-ab51-db259ef2825d
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