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      Development of a UPLC-TQ/MS Approach for the Determination of Eleven Bioactive Components in Haizao Yuhu Decoction Plus-Minus Haizao and Gancao Drug Combination after Oral Administration in a Rat Model of Hypothyroidism

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          Abstract

          Haizao Yuhu Decoction (HYD) has been used for approximately 500 years and is well-known in Traditional Chinese Medicine for its efficacy in the treatment of thyroid-related diseases. In this study, a rapid liquid chromatography-tandem mass spectrometry method was developed for the determination of liquiritin, naringin, hesperidin, peimine, liquiritigenin, glycyrrhizic acid, bergapten, nobiletin, osthole, and glycyrrhetinic acid in rat plasma to investigate the pharmacokinetic profile of different HYD prescriptions in a rat model of hypothyroidism. The differences in pharmacokinetic parameters among the groups were compared by Student’s t-test. The pharmacokinetic profile of liquiritin, naringin, hesperidin, peimine, liquiritigenin, glycyrrhizic acid, bergapten, nobiletin, osthole, and glycyrrhetinic acid showed significant differences between Haizao and Gancao anti-drug combination and other herbs in HYD. These results may contribute to the rational clinical use of HYD and reveal the compatibility profile of the Haizao and Gancao anti-drug combination.

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          Traditional medicine: a culture in the balance.

          K. Qiu (2007)
          Article 0 comments Cited 96 times – based on 0 reviews     Review now
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            Purification, antitumor and antioxidant activities in vitro of polysaccharides from the brown seaweed Sargassum pallidum.

            Jiang-hong Ye, Keqi Wang, Chunhong Zhou … (2008)
            Supercritical CO2 extraction, ultrasonic-aid extraction and membrane separation technology were applied to prepare Sargassum pallidum polysaccharides (SP). Three main fractions, SP-1, SP-2 and SP-3, were obtained by membranes of 1.0×10(-4)mm pore size and normal molecular-weight cut-off of 50kDa. The resulting three preparations were further purified by DEAE Cellulose-52 chromatography to afford seven polysaccharide fractions. Furthermore, the antitumor and antioxidant activities, in vitro, of the polysaccharide fractions were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay and DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical-scavenging assay, respectively. SP-3-1 and SP-3-2 showed significantly higher antitumor activity against the HepG2 cells, A549 cells, and MGC-803 cells. SP-3 had the highest sulfate content (22.6%). These results indicate that the higher antitumor activity of SP-3-1 and SP-3-2 from SP-3 with lower molecular weights may be related to their molecular weights and sulfate contents. The antioxidant activities of SP-1, SP-2 and SP-3 were low at the tested concentration.
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              Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction.

              Peng Li, Weiyang Tao, Chunli Zheng … (2013)
              The main therapeutic concept in Traditional Chinese Medicine (TCM) is herb formula, which treats various diseases via potential herb interactions to maximize the efficacy and minimize the adverse effects. However, the combination principle of herb formula still remains a mystery due to the lack of appropriate methods. A systems pharmacology method integrating the pharmacokinetic analysis, drug targeting, and drug-target-disease network is developed to dissect this rule embedded in the herbal formula. All these are exemplified by a representative TCM formula, Ma-huang decoction, made up of four botanic herbs. Based on the deep investigation of the function and compatibility of each herb, in a molecular/systems level, we demonstrate the different pharmacological roles that each herb might play in the prescription. By the way of enhancing the bioavailability and/or making the pharmacological synergy among different herbs, the four herbs effectively combine together to be suitable for treating diseases. The present work lays foundations for a more comprehensive understanding of the combination rule of TCM, which might also be beneficial to drug development and applications. Crown Copyright © 2013 Published by Elsevier Ireland Ltd. All rights reserved.
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                Author and article information

                Contributors
                Derek J. McPhee: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 22 December 2016
                Publication date Collection: January 2017
                Volume: 22
                Issue: 1
                Electronic Location Identifier: 7
                Affiliations
                [1 ]Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China; kittyma128@ 123456sohu.com (Y.M.); zy91923@ 123456163.com (Y.Z.); zhaiyanjuan1990@ 123456126.com (Y.Z.); 04040416@ 123456163.com (Z.Z.); ptianxie@ 123456126.com (Y.P.); qiandwnj@ 123456126.com (D.Q.); sushulan1974@ 123456163.com (S.S.)
                [2 ]Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China
                Author notes
                [* ]Correspondence: fanxsh126@ 123456126.com (X.F.); dja@ 123456njutcm.edu.cn (J.D.); Tel./Fax: +86-258-5811-945 (X.F.); +86-258-5811-116 (J.D.)
                Article
                Publisher ID: molecules-22-00007
                DOI: 10.3390/molecules22010007
                PMC ID: 6155732
                PubMed ID: 28025523
                SO-VID: 1c3cd7e0-6906-4677-9fe5-048dadbbfbb1
                Copyright © © 2016 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 29 August 2016
                Date accepted : 19 December 2016
                Categories
                Subject: Article

                Keywords: haizao yuhu decoction,hypothyroidism,multiple components,pharmacokinetic differences,uplc-tq/ms
                Data availability:
                Keywords: haizao yuhu decoction, hypothyroidism, multiple components, pharmacokinetic differences, uplc-tq/ms

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