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      Absence of Lipolytic Activity from Purified Human Growth Hormone in Cultured 3T3-L1 Adipocytes

      a , b , a

      Hormone Research in Paediatrics

      S. Karger AG

      Lipolysis, Growth hormone, 3T3-L1 adipocytes

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          Abstract

          Although standard preparations of growth hormone activated hormone-sensitive lipase in differentiated 3T3-L1 adipocytes, more highly purified preparations of human and bovine hormones were not lipolytic in this system. We found that the standard preparations were contaminated with a lipolytic substance which was removed during purification of the growth hormone. The purified growth hormone likewise did not stimulate lipolysis in adipose tissue from fasted rats. Dexamethasone had no potentiating activity in either assay.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1983
          1983
          26 November 2008
          : 17
          : 4
          : 197-201
          Affiliations
          aWhittier Institute for Diabetes and Endocrinology, La Jolla, Calif.; bDivision of Metabolic Disease, Department of Medicine, University of California San Diego, La Jolla, Calif., USA
          Article
          179698 Horm Res 1983;17:197–201
          10.1159/000179698
          6884983
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
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