Absence of Lipolytic Activity from Purified Human Growth Hormone in Cultured 3T3-L1 Adipocytes

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Abstract

Although standard preparations of growth hormone activated hormone-sensitive lipase in differentiated 3T3-L1 adipocytes, more highly purified preparations of human and bovine hormones were not lipolytic in this system. We found that the standard preparations were contaminated with a lipolytic substance which was removed during purification of the growth hormone. The purified growth hormone likewise did not stimulate lipolysis in adipose tissue from fasted rats. Dexamethasone had no potentiating activity in either assay.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1983

Publication date (Print): 1983

Publication date (Electronic): 26 November 2008

Volume: 17

Issue: 4

Pages: 197-201

Affiliations

^aWhittier Institute for Diabetes and Endocrinology, La Jolla, Calif.; ^bDivision of Metabolic Disease, Department of Medicine, University of California San Diego, La Jolla, Calif., USA

Article

Publisher ID: 179698 Other ID: Horm Res 1983;17:197–201

DOI: 10.1159/000179698

PubMed ID: 6884983

SO-VID: 1c689b68-b48f-4892-9392-e68bb39b9113

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 09 June 1982

Date accepted : 27 October 1982

Page count

Pages: 5

Absence of Lipolytic Activity from Purified Human Growth Hormone in Cultured 3T3-L1 Adipocytes

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Karger: Endocrinology

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