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Angiogenesis inhibition: A review
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Abstract
In this review we discuss the concept of anti-angiogenesis, which is the inhibition
of neovascularization. Anti-angiogenic agents are viewed from the standpoint of their
effect on various elements of the angiogenic process, including induction of vascular
discontinuity, endothelial cell movement, endothelial cell proliferation, and three-dimensional
restructuring of patent vessels. An effort is made to place the many different approaches
to anti-angiogenesis research into a comprehensible structure, in order to identify
problems of evaluation and interpretation, thereby providing a clearer basis for determining
promising and needed directions for further investigation.