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      Early Changes in the Choroidal Vasculature of Rats Occurring with Experimentally Induced Hypertension

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          Abstract

          We investigated the early changes in the choroidal vasculature in rats following surgically induced renovascular hypertension. Renovascular hypertension was induced in a group of 12 male Wistar rats using a modified Goldblatt procedure. The rats were divided into four groups, each being sacrificed at weekly intervals, the first group being sacrificed 1 week following the procedure. Vascular casts were prepared of the choroidal circulation using acyl resin (mercox). These were then studied using the scanning electron microscope. No abnormality of the choroidal circulation was noted for the first 2 weeks. At 3 weeks, when a rise in the average mean arterial pressure was noted, nodular lesions were seen in the choroidal arteries and choriocapillaris. These lesions were present in far greater numbers by 4 weeks. It seems likely that the nodular lesions described are microaneurysms and may contribute to the pathogenesis of the clinically described Elschnig spot.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1996
          1996
          11 December 2009
          : 28
          : 4
          : 255-259
          Affiliations
          aDepartment of Ophthalmology, University College Dublin, Mater Misericordiae Hospital, and bDepartment of Human Anatomy and Physiology, University College Dublin, Ireland
          Article
          267911 Ophthalmic Res 1996;28:255–259
          10.1159/000267911
          8878189
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Vision sciences, Ophthalmology & Optometry, Pathology

          Hypertension, Elschnig spot, Microaneurysm, Choroid

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