The adaptive evolution of cultural ecosystems is a distinctive process along the Silk Road in China, involving the transitional interaction of nature and culture. This study aims to provide theoretical recommendations for the management of cultural heritage sites along the Silk Road to assess the values and keep the balance between tourism development and cultural heritage protection. The paper focuses on 22 cultural sites in western China to study the adaptive evolution pattern of cultural landscapes along the Silk Road with landscape changes and the transmission patterns of modern cultural tourism. Based on relevant literature reviews, historical maps, and geomorphological maps, the factors influencing the evolution of the cultural ecosystem are explored. We present both the theoretical and managerial implications: the cultural heritage of the urban areas can vigorously develop the cultural tourism with a high degree of industrialization, suburban areas can boost up traditional tourism product routes. We also assume that the degree of development of cultural tourism depends on the cultural ecosystem service and the environmental status of the cultural landscape.