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      HAA1 and PRS3 overexpression boosts yeast tolerance towards acetic acid improving xylose or glucose consumption: unravelling the underlying mechanisms

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          Improved method for high efficiency transformation of intact yeast cells.

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            Is Open Access

            Pretreatment of lignocellulose: Formation of inhibitory by-products and strategies for minimizing their effects.

            Biochemical conversion of lignocellulosic feedstocks to advanced biofuels and other commodities through a sugar-platform process involves a pretreatment step enhancing the susceptibility of the cellulose to enzymatic hydrolysis. A side effect of pretreatment is formation of lignocellulose-derived by-products that inhibit microbial and enzymatic biocatalysts. This review provides an overview of the formation of inhibitory by-products from lignocellulosic feedstocks as a consequence of using different pretreatment methods and feedstocks as well as an overview of different strategies used to alleviate problems with inhibitors. As technologies for biorefining of lignocellulose become mature and are transferred from laboratory environments to industrial contexts, the importance of management of inhibition problems is envisaged to increase as issues that become increasingly relevant will include the possibility to use recalcitrant feedstocks, obtaining high product yields and high productivity, minimizing the charges of enzymes and microorganisms, and using high solids loadings to obtain high product titers.
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              Fuel ethanol production from lignocellulosic biomass: An overview on feedstocks and technological approaches

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                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                Applied Microbiology and Biotechnology
                Appl Microbiol Biotechnol
                Springer Science and Business Media LLC
                0175-7598
                1432-0614
                May 2018
                April 2 2018
                May 2018
                : 102
                : 10
                : 4589-4600
                Article
                10.1007/s00253-018-8955-z
                29607452
                1cea5c63-f85b-46d9-abc9-f18b6ea04c1e
                © 2018

                http://www.springer.com/tdm

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