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      Temporal variations in the erythrocyte permeability to bupivacaine, etidocaine and mepivacaine in mice.

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      Life sciences

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          Abstract

          Temporal changes in membrane permeability to bupivacaine (B), etidocaine (E) and mepivacaine (M) documented by their erythrocytic penetration were studied in mice. Temporal variations of B, E and M erythrocytic penetration were demonstrated with a maximum at 04.00 h for B (amplitude = 148%), 10.00 h for E (amplitude = 146%) and at 10.00 h for M (amplitude = 75%). Differences in the circadian pattern of erythrocytic penetration of B, E and M are discussed according to physicochemical properties of these three agents.

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          Author and article information

          Journal
          Life Sci.
          Life sciences
          0024-3205
          0024-3205
          1989
          : 45
          : 26
          Affiliations
          [1 ] Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille.
          Article
          0024-3205(89)90243-9
          10.1016/0024-3205(89)90243-9
          2615557
          1d014a17-13ae-4492-9a06-4bab8ffe3e9a
          History

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