A Comparison of the Effectiveness of Anisodamine and Norepinephrine on Hemorrhagic Shock in Rabbits

Abstract

Hemorrhagic shock was experimentally produced in 123 rabbits which were divided into control groups and groups treated separately with anisodamine and norepinephrine. A comparison of their effect on the arterial blood pressure and mortality has shown that anisodamine has a much better therapeutic effect. However, without simultaneous and adequate volume replacement anisodamine appears to produce some harmful effects on rabbits in shock. It is suggested that the mechanism of its antishock effect lies in dilating the spastic arterioles present under shock conditions, and improving the microcirculation whereas norepinephrine on the contrary aggravates the microcirculatory disturbance through its vasoconstrictive action.