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      A Comparison of the Effectiveness of Anisodamine and Norepinephrine on Hemorrhagic Shock in Rabbits

      Cardiology

      S. Karger AG

      Catecholamines, Cholinergic blocker, Blood volume replacement, Vasodilator effect, Microcirculation

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          Abstract

          Hemorrhagic shock was experimentally produced in 123 rabbits which were divided into control groups and groups treated separately with anisodamine and norepinephrine. A comparison of their effect on the arterial blood pressure and mortality has shown that anisodamine has a much better therapeutic effect. However, without simultaneous and adequate volume replacement anisodamine appears to produce some harmful effects on rabbits in shock. It is suggested that the mechanism of its antishock effect lies in dilating the spastic arterioles present under shock conditions, and improving the microcirculation whereas norepinephrine on the contrary aggravates the microcirculatory disturbance through its vasoconstrictive action.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1978
          1978
          31 October 2008
          : 63
          : 3
          : 160-167
          Article
          170572 Cardiology 1978;63:160–167
          10.1159/000170572
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 8
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