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      Down-regulation of miR-23b induces phenotypic switching of vascular smooth muscle cells in vitro and in vivo.

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          Abstract

          Phenotypic switch of vascular smooth muscle cells (VSMCs) plays a key role in the pathogenesis of different vascular diseases, such as atherosclerosis and restenosis after coronary intervention. MicroRNAs have been identified as key regulators of VSMC biology. The miR-23b is highly expressed in VSMCs and it is involved in differentiation, proliferation, and migration of several non-vascular cell types. However, the role of miR-23b in vascular disease is currently unknown. Thus, the aim of the present study was to evaluate the role of miR-23b on VSMC phenotypic switch in vitro and after vascular injury in vivo.

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          Author and article information

          Journal
          Cardiovasc. Res.
          Cardiovascular research
          Oxford University Press (OUP)
          1755-3245
          0008-6363
          Sep 01 2015
          : 107
          : 4
          Affiliations
          [1 ] Laboratory of Molecular and Cellular Cardiology, Cardiovascular Institute, Magna Graecia University, Catanzaro, Italy.
          [2 ] Laboratory of Molecular and Cellular Cardiology, Cardiovascular Institute, Magna Graecia University, Catanzaro, Italy URT-CNR, Magna Graecia University, Catanzaro 88100, Italy indolfi@unicz.it.
          Article
          cvv141
          10.1093/cvr/cvv141
          25994172
          1d06130b-4cce-4cc4-8830-4b9976b62fc1
          History

          FoxO4,MicroRNAs,Phenotypic switch,Restenosis,Vascular smooth muscle cells

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