Blog
About

4
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The war against influenza: discovery and development of sialidase inhibitors.

      Nature reviews. Drug discovery

      pharmacology, Zanamivir, Oseltamivir, antagonists & inhibitors, Neuraminidase, virology, prevention & control, drug therapy, Influenza, Human, Humans, Antiviral Agents, Animals

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The threat of a major human influenza pandemic, in particular from highly aggressive strains such as avian H5N1, has emphasized the need for therapeutic strategies to combat these pathogens. At present, two inhibitors of sialidase (also known as neuraminidase), a viral enzyme that has a key role in the life cycle of influenza viruses, would be the mainstay of pharmacological strategies in the event of such a pandemic. This article provides a historical perspective on the discovery and development of these drugs--zanamivir and oseltamivir--and highlights the value of structure-based drug design in this process.

          Related collections

          Author and article information

          Journal
          10.1038/nrd2400
          18049471

          Comments

          Comment on this article