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      Recent advances of functional nucleic acids-based electrochemiluminescent sensing

      , , , ,
      Biosensors and Bioelectronics
      Elsevier BV

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          Nucleic acid junctions and lattices.

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            Dynamic DNA nanotechnology using strand-displacement reactions.

            The specificity and predictability of Watson-Crick base pairing make DNA a powerful and versatile material for engineering at the nanoscale. This has enabled the construction of a diverse and rapidly growing set of DNA nanostructures and nanodevices through the programmed hybridization of complementary strands. Although it had initially focused on the self-assembly of static structures, DNA nanotechnology is now also becoming increasingly attractive for engineering systems with interesting dynamic properties. Various devices, including circuits, catalytic amplifiers, autonomous molecular motors and reconfigurable nanostructures, have recently been rationally designed to use DNA strand-displacement reactions, in which two strands with partial or full complementarity hybridize, displacing in the process one or more pre-hybridized strands. This mechanism allows for the kinetic control of reaction pathways. Here, we review DNA strand-displacement-based devices, and look at how this relatively simple mechanism can lead to a surprising diversity of dynamic behaviour.
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              Graphene and graphene oxide: biofunctionalization and applications in biotechnology

              Graphene is the basic building block of 0D fullerene, 1D carbon nanotubes, and 3D graphite. Graphene has a unique planar structure, as well as novel electronic properties, which have attracted great interests from scientists. This review selectively analyzes current advances in the field of graphene bioapplications. In particular, the biofunctionalization of graphene for biological applications, fluorescence-resonance-energy-transfer-based biosensor development by using graphene or graphene-based nanomaterials, and the investigation of graphene or graphene-based nanomaterials for living cell studies are summarized in more detail. Future perspectives and possible challenges in this rapidly developing area are also discussed.
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                Author and article information

                Contributors
                Journal
                Biosensors and Bioelectronics
                Biosensors and Bioelectronics
                Elsevier BV
                09565663
                November 2021
                November 2021
                : 191
                : 113462
                Article
                10.1016/j.bios.2021.113462
                1d5b36bf-c247-4023-a250-24f4f38cb719
                © 2021

                https://www.elsevier.com/tdm/userlicense/1.0/

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