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      Management of hyperlipidemia in children with refractory nephrotic syndrome: The effect of statin therapy

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      The Journal of Pediatrics
      Elsevier BV

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          Abstract

          The efficacy and safety of hydroxymethylglutaric coenzyme A reductase inhibitor (statins) in the treatment of hyperlipidemia were evaluated in 12 infants and children with steroid-resistant nephrotic syndrome followed prospectively for 1 to 5 years. All patients experienced a hypolipidemic response with a marked reduction in their total cholesterol (40%), low-density lipoprotein cholesterol (44%), and triglyceride levels (33%), but no appreciable change in high-density lipoprotein cholesterol. Statin therapy was well tolerated without clinical or laboratory adverse effects. In spite of a significant hypolipidemic response to statin therapy there were no changes observed in the degree of proteinuria, hypoalbuminemia, or in the rate of progression to chronic renal failure. Long-term controlled studies with statin therapy are needed to further document or negate their renoprotective role in refractory nephrotic syndrome.

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          Author and article information

          Journal
          The Journal of Pediatrics
          The Journal of Pediatrics
          Elsevier BV
          00223476
          March 1997
          March 1997
          : 130
          : 3
          : 470-474
          Article
          10.1016/S0022-3476(97)70213-0
          9063427
          1d7b9ae8-af51-4c7d-936a-2967b296b3e0
          © 1997

          https://www.elsevier.com/tdm/userlicense/1.0/

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