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      Continuing rise in oropharyngeal cancer in a high HPV prevalence area: A Danish population-based study from 2011 to 2014.

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          Abstract

          Human papillomavirus (HPV) is a critical element in the rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), although whether this trend will continue, and the types of HPV responsible, are currently unknown. We previously demonstrated an increased incidence of HPV-related OPSCC in the high HPV prevalence area of Eastern Denmark from 2000 to 2010. Therefore, we investigated if the incidence for OPSCC continued to rise, the association to HPV and putative HPV-types in Eastern Denmark from 2011 to 14. We then projected the expected incidence of OPSCC versus cervical cancer through to 2020.

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          Author and article information

          Journal
          Eur. J. Cancer
          European journal of cancer (Oxford, England : 1990)
          Elsevier BV
          1879-0852
          0959-8049
          Jan 2017
          : 70
          Affiliations
          [1 ] Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark.
          [2 ] Department of Pathology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark.
          [3 ] Department of Pathology, Roskilde Sygehus, Sygehusvej 9, 4000 Roskilde, Denmark.
          [4 ] Department of Pathology, Hvidovre Hospital, Kettegaard Alle 30, 2650 Hvidovre, Denmark.
          [5 ] Department of Pathology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev Ringvej 75, 2730 Herlev, Denmark.
          [6 ] Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen Oe, Denmark; Department of Gynaecology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark.
          [7 ] Institute of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
          [8 ] Department of Oncology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark.
          [9 ] Department of Oncology, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark.
          [10 ] Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark.
          [11 ] Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark. Electronic address: Christian.von.buchwald@regionh.dk.
          Article
          S0959-8049(16)32499-6
          10.1016/j.ejca.2016.10.015
          27888679
          1d8099e2-6403-41f9-9f7f-5573699f7378
          History

          Oropharynx,Tonsillar,p16,Base of tongue,Genotype,HPV,HPV16,Incidence
          Oropharynx, Tonsillar, p16, Base of tongue, Genotype, HPV, HPV16, Incidence

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