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      Schistosoma japonicum-derived peptide SJMHE1 promotes peripheral nerve repair through a macrophage-dependent mechanism

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          Abstract

          Peripheral nerve injury, a disease that affects 1 million people worldwide every year, occurs when peripheral nerves are destroyed by injury, systemic illness, infection, or an inherited disorder. Indeed, repair of damaged peripheral nerves is predominantly mediated by type 2 immune responses. Given that helminth parasites induce type 2 immune responses in hosts, we wondered whether helminths or helminth-derived molecules might have the potential to improve peripheral nerve repair. Here, we demonstrated that schistosome-derived SJMHE1 promoted peripheral myelin growth and functional regeneration via a macrophage-dependent mechanism and simultaneously increased the induction of M2 macrophages. Our findings highlight the therapeutic potential of schistosome-derived SJMHE1 for improving peripheral nerve repair.

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          Author and article information

          Journal
          Am J Transl Res
          Am J Transl Res
          ajtr
          American Journal of Translational Research
          e-Century Publishing Corporation
          1943-8141
          2021
          15 March 2021
          : 13
          : 3
          : 1290-1306
          Affiliations
          [1 ] State Key Lab of Reproductive Medicine, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Center for Global Health, Nanjing Medical University Nanjing 211166, Jiangsu, P. R. China
          [2 ] Department of Neurology Laboratory, Jintan Hospital, Jiangsu University Jintan, Changzhou 213200, Jiangsu, P. R. China
          [3 ] Department of Nuclear Medicine and Institute of Oncology, The Affiliated Hospital of Jiangsu University Zhenjiang 212000, Jiangsu, P. R. China
          [4 ] Department of Central Laboratory, The Affiliated Hospital of Jiangsu University Zhenjiang 212000, Jiangsu, P. R. China
          Author notes
          Address correspondence to: Drs. Chuan Su and Xiaojun Chen, State Key Lab of Reproductive Medicine, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, Center for Global Health, Nanjing Medical University, Nanjing 211166, Jiangsu, P. R. China. E-mail: chuansu@ 123456njmu.edu.cn (CS); chenxiaojun@ 123456njmu.edu.cn (XJC); Dr. Xuefeng Wang, Department of Central Laboratory, The Affiliated Hospital of Jiangsu University, Zhenjiang 212000, Jiangsu, P. R. China. E-mail: xuefengwang@ 123456ujs.edu.cn
          Article
          PMC8014408 PMC8014408 8014408
          8014408
          33841657
          1da3906e-7a2a-411a-be87-88d5e0cdc917
          AJTR Copyright © 2021
          History
          : 21 July 2020
          : 11 December 2020
          Categories
          Original Article

          macrophage,Peripheral nerve regeneration,neuroregeneration,myelination

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