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      Combination therapy of eicosapentaenoic acid and pitavastatin for coronary plaque regression evaluated by integrated backscatter intravascular ultrasonography (CHERRY study)-rationale and design.

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          Abstract

          Many clinical trials have shown that 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can significantly reduce coronary artery disease in both primary and secondary prevention. A recent study showed that aggressive lipid-lowering therapy with strong statins could achieve coronary artery plaque regression, as evaluated with gray-scale intravascular ultrasound (IVUS). However, it is unknown whether coronary plaque regression and stabilization are reinforced when eicosapentaenoic acid (EPA) is used with a strong statin.

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          Author and article information

          Journal
          J Cardiol
          Journal of cardiology
          Elsevier BV
          1876-4738
          0914-5087
          Sep 2014
          : 64
          : 3
          Affiliations
          [1 ] Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan. Electronic address: tewatana@med.id.yamagata-u.ac.jp.
          [2 ] Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
          [3 ] Yamagata Prefectural Shinjyo Hospital, Yamagata, Japan.
          [4 ] Yamagata Prefectural Central Hospital, Yamagata, Japan.
          [5 ] Nihonkai General Hospital, Yamagata, Japan.
          [6 ] Okitama Public General Hospital, Yamagata, Japan.
          [7 ] Yamagata City Hospital Saiseikan, Yamagata, Japan.
          [8 ] Department of Public Health, Yamagata University School of Medicine, Yamagata, Japan.
          Article
          S0914-5087(14)00011-2
          10.1016/j.jjcc.2013.12.008
          24503140
          1dbb155b-45d4-4da9-95b9-2f69c4ee4a7a
          History

          Cholesterol-lowering drugs,Coronary artery disease,Fish oils,Intravascular ultrasound/Doppler,Plaque

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