13
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family-based association study in the Bulgarian population.

      Acta Psychiatrica Scandinavica
      Adult, Aged, Bipolar Disorder, genetics, Bulgaria, epidemiology, Dopamine Plasma Membrane Transport Proteins, Female, Genetic Predisposition to Disease, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins, Middle Aged, Minisatellite Repeats, Nerve Tissue Proteins, Polymerase Chain Reaction, Polymorphism, Genetic, Psychotic Disorders, metabolism, Schizophrenia

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A 40-bp variable number tandem repeat in the 3'-UTR of dopamine transporter gene (DAT1) has been examined for association with major psychiatric disorders in several case-control studies. No significant results have been found. We used a new collection of parent-offspring trios to test for association with schizophrenia (SZ), bipolar 1 disorder (BPI) and schizoaffective (SA) disorder. We genotyped trios from Bulgarian origin where the proband had SZ (178 trios), BPI (77 trios) and SA (29 trios). Alleles ranging from 5 to 11 repeats were observed. The results were analysed with the extended TDT (ETDT). No preferential transmission of alleles was observed for any diagnostic group. The presence of allele DAT*10 was associated with the severity and frequency of auditory hallucinations, however, this result is not significant if corrected for multiple testing. Our results are in agreement with previous reports of a lack of association between this polymorphism and major psychiatric disorders.

          Related collections

          Author and article information

          Comments

          Comment on this article