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      Influence of the Pineal Gland on Hypothalamic Content of TRH in the Syrian Hamster

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Hamster, Pineal gland, TRH, Hypothalamus, Blinding

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          Abstract

          Blinding adult female hamsters by bilateral orbital enucleation caused an increase in thyrotropin-releasing hormone (TRH) content of the medial basal hypothalamus and also led to an increase in TRH content in the remainder of the hypothalamus (dorsal hypothalamus). Although pinealectomy by itself had no significant effect on the neuroendocrine-thyroid axis, this surgical procedure prevented the inhibition of serum thyroxin observed in blinded hamsters. Pinealectomy also prevented the increase in TRH content of medial basal and dorsal hypothalamus observed in blinded hamsters. The results are consistent with the view that the pineal gland has a CNS site of action and provide evidence that the anti-thyroid influence of the pineal gland can be explained by pineal inhibition of TRH release.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1983
          1983
          26 November 2008
          : 17
          : 2
          : 108-113
          Affiliations
          Department of Anatomy, University of Manitoba School of Medicine, Winnipeg, Manitoba, Canada; Department of Medicine, Louisiana State University Medical Center, New Orleans, La., USA
          Article
          179684 Horm Res 1983;17:108–113
          10.1159/000179684
          6404746
          © 1983 S. Karger AG, Basel

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          Pages: 6
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