+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Influence of the Pineal Gland on Hypothalamic Content of TRH in the Syrian Hamster


      Hormone Research in Paediatrics

      S. Karger AG

      Hamster, Pineal gland, TRH, Hypothalamus, Blinding

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Blinding adult female hamsters by bilateral orbital enucleation caused an increase in thyrotropin-releasing hormone (TRH) content of the medial basal hypothalamus and also led to an increase in TRH content in the remainder of the hypothalamus (dorsal hypothalamus). Although pinealectomy by itself had no significant effect on the neuroendocrine-thyroid axis, this surgical procedure prevented the inhibition of serum thyroxin observed in blinded hamsters. Pinealectomy also prevented the increase in TRH content of medial basal and dorsal hypothalamus observed in blinded hamsters. The results are consistent with the view that the pineal gland has a CNS site of action and provide evidence that the anti-thyroid influence of the pineal gland can be explained by pineal inhibition of TRH release.

          Related collections

          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 17
          : 2
          : 108-113
          Department of Anatomy, University of Manitoba School of Medicine, Winnipeg, Manitoba, Canada; Department of Medicine, Louisiana State University Medical Center, New Orleans, La., USA
          179684 Horm Res 1983;17:108–113
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6


          Comment on this article