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      Retracted: Identification of Oxidative Stress-Associated Molecular Subtypes and Signature for Predicting Survival Outcome of Cervical Squamous Cell Carcinoma

      retraction
      Oxidative Medicine and Cellular Longevity
      Hindawi

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          Abstract

          This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation The presence of these indicators undermines our confidence in the integrity of the article's content and we cannot, therefore, vouch for its reliability. Please note that this notice is intended solely to alert readers that the content of this article is unreliable. We have not investigated whether authors were aware of or involved in the systematic manipulation of the publication process. Wiley and Hindawi regrets that the usual quality checks did not identify these issues before publication and have since put additional measures in place to safeguard research integrity. We wish to credit our own Research Integrity and Research Publishing teams and anonymous and named external researchers and research integrity experts for contributing to this investigation. The corresponding author, as the representative of all authors, has been given the opportunity to register their agreement or disagreement to this retraction. We have kept a record of any response received.

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          Identification of Oxidative Stress-Associated Molecular Subtypes and Signature for Predicting Survival Outcome of Cervical Squamous Cell Carcinoma

          Background Cervical squamous cell carcinoma (CESC) is the gynecologic malignancy with high incidence rate and high mortality rate. Oxidative stress participates in gene regulation and malignant tumor progression, including CESC. Methods RNA-seq, clinical information, and genomic mutation were from The Cancer Genome Atlas- (TCGA-) CESC and GSE44001 datasets. Oxidative stress-related genes were obtained from the gene set enrichment analysis (GSEA) website. ConsensusClusterPlus was used for clustering, which was assessed by the Kaplan-Meier (KM) survival curve analysis, mutation analysis, immunocharacteristic analysis, and therapy. Prognostic signatures were built by combining weighted correlation network analysis (WGCNA), least absolute shrinkage and selection operator (LASSO) algorithm, and stepAIC. The prognostic power of this model was evaluated using the KM survival curve analysis, receiver operating characteristic (ROC) curve analysis, nomogram, and decision curve analysis (DCA). Results 218 of the 291 CESC cases (74.91%) presented oxidative stress-related gene mutation, especially FBXW7. Three clusters were determined based on oxidative stress-related genes, among which cluster 3 (C3) presented low-frequency mutation and hyperimmune state and was sensitive to immunotherapy. This research developed a 5-gene oxidative stress-related prognostic signature and a RiskScore model. As shown by ROC analysis, in the TCGA and GSE44001 datasets, the RiskScore model showed a high prediction accuracy for 1-, 3-, and 5-year CESC overall survival. High RiskScore was associated with enhanced immune status. The nomogram model was greatly predictive of the overall survival of CESC patients. Conclusion Our prognostic model was based on oxidative stress-related genes in CESC, potentially aids in CESC prognosis, and provides potential targets against CESC.
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            Author and article information

            Contributors
            Journal
            Oxid Med Cell Longev
            Oxid Med Cell Longev
            OMCL
            Oxidative Medicine and Cellular Longevity
            Hindawi
            1942-0900
            1942-0994
            2023
            2 August 2023
            2 August 2023
            : 2023
            : 9795318
            Affiliations
            Article
            10.1155/2023/9795318
            10412189
            36225179
            1df45e3e-04aa-4281-96e9-f59379d73b39
            Copyright © 2023 Oxidative Medicine and Cellular Longevity.

            This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

            History
            : 1 August 2023
            : 1 August 2023
            Categories
            Retraction

            Molecular medicine
            Molecular medicine

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