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      Bicycling Exercise Helps Maintain a Youthful Metabolic Cost of Walking in Older Adults

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          Abstract

          The decline of walking performance is a key determinant of morbidity among older adults. Healthy older adults have been shown to have a 15–20% lower walking economy compared with young adults. However, older adults who run for exercise have a higher walking economy compared with older adults who walk for exercise. Yet, it remains unclear if other aerobic exercises yield similar improvements on walking economy. The purpose of this study was to determine if regular bicycling exercise affects walking economy in older adults. We measured metabolic rate while 33 older adult “bicyclists” or “walkers” and 16 young adults walked on a level treadmill at four speeds between (0.75–1.75 m/s). Across the range of speeds, older bicyclists had a 9–17% greater walking economy compared with older walkers ( p = .009). In conclusion, bicycling exercise mitigates the age-related deterioration of walking economy, whereas walking for exercise has a minimal effect on improving walking economy.

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          Oxidative capacity and ageing in human muscle.

          Kevin Conley, Sharon A Jubrias, Peter Esselman (2000)
          This study determined the decline in oxidative capacity per volume of human vastus lateralis muscle between nine adult (mean age 38.8 years) and 40 elderly (mean age 68.8 years) human subjects (age range 25-80 years). We based our oxidative capacity estimates on the kinetics of changes in creatine phosphate content ([PCr]) during recovery from exercise as measured by (31)P magnetic resonance (MR) spectroscopy. A matched muscle biopsy sample permitted determination of mitochondrial volume density and the contribution of the loss of mitochondrial content to the decline in oxidative capacity with age. The maximal oxidative phosphorylation rate or oxidative capacity was estimated from the PCr recovery rate constant (k(PCr)) and the [PCr] in accordance with a simple electrical circuit model of mitochondrial respiratory control. Oxidative capacity was 50 % lower in the elderly vs. the adult group (0.61 +/- 0.04 vs. 1.16 +/- 0.147 mM ATP s(-1)). Mitochondrial volume density was significantly lower in elderly compared with adult muscle (2.9 +/- 0.15 vs. 3.6 +/- 0.11 %). In addition, the oxidative capacity per mitochondrial volume (0.22 +/- 0.042 vs. 0.32 +/- 0.015 mM ATP (s %)(-1)) was reduced in elderly vs. adult subjects. This study showed that elderly subjects had nearly 50 % lower oxidative capacity per volume of muscle than adult subjects. The cellular basis of this drop was a reduction in mitochondrial content, as well as a lower oxidative capacity of the mitochondria with age.
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            Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults.

            Stephanie Wohlgemuth, Giovanna Distefano, Christiaan Leeuwenburgh … (2013)
            Lower ambulatory performance with aging may be related to a reduced oxidative capacity within skeletal muscle. This study examined the associations between skeletal muscle mitochondrial capacity and efficiency with walking performance in a group of older adults. Thirty-seven older adults (mean age 78 years; 21 men and 16 women) completed an aerobic capacity (VO2 peak) test and measurement of preferred walking speed over 400 m. Maximal coupled (State 3; St3) mitochondrial respiration was determined by high-resolution respirometry in saponin-permeabilized myofibers obtained from percutanous biopsies of vastus lateralis (n = 22). Maximal phosphorylation capacity (ATPmax) of vastus lateralis was determined in vivo by (31)P magnetic resonance spectroscopy (n = 30). Quadriceps contractile volume was determined by magnetic resonance imaging. Mitochondrial efficiency (max ATP production/max O2 consumption) was characterized using ATPmax per St3 respiration (ATPmax/St3). In vitro St3 respiration was significantly correlated with in vivo ATPmax (r (2) = .47, p = .004). Total oxidative capacity of the quadriceps (St3*quadriceps contractile volume) was a determinant of VO2 peak (r (2) = .33, p = .006). ATPmax (r (2) = .158, p = .03) and VO2 peak (r (2) = .475, p < .0001) were correlated with preferred walking speed. Inclusion of both ATPmax/St3 and VO2 peak in a multiple linear regression model improved the prediction of preferred walking speed (r (2) = .647, p < .0001), suggesting that mitochondrial efficiency is an important determinant for preferred walking speed. Lower mitochondrial capacity and efficiency were both associated with slower walking speed within a group of older participants with a wide range of function. In addition to aerobic capacity, lower mitochondrial capacity and efficiency likely play roles in slowing gait speed with age.
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              The heart rate method for estimating metabolic rate: review and recommendations.

              Stefan Green (2011)
              Under most circumstances heart rate (f(H)) is correlated with the rate of oxygen consumption (VO(2)) and hence the rate of energy expenditure or metabolic rate (MR). For over 60 years this simple principle has underpinned the use of heart rate to estimate metabolic rate in a range of animal species and to answer questions about their physiology, behaviour and ecology. The heart rate method can be applied both quantitatively and qualitatively. The quantitative approach is a two-stage process where firstly f(H) and MR are measured simultaneously under controlled conditions and a predictive calibration relationship derived. Secondly, measurements of heart rate are made and converted to estimates of MR using the calibration relationship. The qualitative approach jumps directly to the second stage, comparing estimates of f(H) under different circumstances and drawing conclusions about MR under the assumption that a relationship exists. This review describes the range of studies which have adopted either the quantitative or qualitative approach to estimating the MR of birds, mammals and reptiles. Studies have tended to focus on species, states and questions which are hard to measure, control or define using other techniques. For example, species studied include large, wide-ranging species such as ungulates, marine predators, and domestic livestock while research questions have concerned behaviours such as flight, diving and the effects of stress. In particular, the qualitative approach has applied to circumstances and/or species where it may be hard or impossible to derive a calibration relationship for practical reasons. The calibration process itself can be complex and a number of factors such as body mass, activity state and stress levels can affect the relationship between f(H) and VO(2). I recommend that a quantitative approach be adopted wherever possible but that this may entail deriving a calibration relationship which is practical and applicable, rather than the most accurate possible. I conclude with a series of recommendations for the application and development of this method. Copyright © 2010 Elsevier Inc. All rights reserved.
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                Author and article information

                Journal
                Title: Journal of Aging and Physical Activity
                Publisher: Human Kinetics
                ISSN (Print): 1063-8652
                ISSN (Electronic): 1543-267X
                Publication date Created: 2020
                Publication date (Print): 2020
                Pages: 1-7
                Article
                DOI: 10.1123/japa.2019-0327
                PubMed ID: 32723930
                SO-VID: 1df78f3b-f6cd-47bd-a3bd-dc05345d6e5f
                Copyright © © 2020
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