Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness.

van Hunnik, Arne; Lau, Dennis H; Zeemering, Stef; Kuiper, Marion; Verheule, Sander; Schotten, Ulrich

doi:10.1016/j.hrthm.2015.12.009

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Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness.

Author(s): Arne van Hunnik ¹ , Dennis H Lau ¹ , Stef Zeemering ¹ , Marion Kuiper ¹ , Sander Verheule ¹ , Ulrich Schotten ²

Publication date (Electronic): Apr 2016

Journal: Heart rhythm

Publisher: Elsevier BV

Keywords: AVE0118, Antiarrhythmic drugs, Atrial fibrillation, Flecainide, In vivo model, Remodeling, Vernakalant

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Abstract

Vernakalant inhibits several potassium currents and causes a rate- and voltage-dependent inhibition of the sodium current.

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Journal ID (iso-abbrev): Heart Rhythm

Title: Heart rhythm

Publisher: Elsevier BV

ISSN (Electronic): 1556-3871

ISSN (Print): 1547-5271

Publication date (Electronic): Apr 2016

Volume: 13

Issue: 4

Affiliations

[1 ] Department of Physiology, Faculty of Medicine, Maastricht University, Maastricht, The Netherlands.

[2 ] Department of Physiology, Faculty of Medicine, Maastricht University, Maastricht, The Netherlands. Electronic address: schotten@maastrichtuniversity.nl.

Article

Publisher Item ID: S1547-5271(15)01522-2

DOI: 10.1016/j.hrthm.2015.12.009

PubMed ID: 26681610

SO-VID: 1df84b6b-7387-43df-aaf2-fa98b16a05e2

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Keywords: In vivo model,Antiarrhythmic drugs,AVE0118,Vernakalant,Remodeling,Flecainide,Atrial fibrillation

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Keywords: In vivo model, Antiarrhythmic drugs, AVE0118, Vernakalant, Remodeling, Flecainide, Atrial fibrillation

Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness.

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Karger: Cardiovascular System

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