Blog
About

4
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Increasing amyloid peptide precursor production and its impact on Alzheimer's disease.

      1

      Neurobiology of aging

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Amyloid peptide precursor (APP) gene expression increases in the brains of patients with Alzheimer's disease (AD). Regulation of expression at the transcriptional and posttranscriptional levels contributes significantly to these increases. Polypeptide hormones stimulate the promoter of the APP gene resulting in increased levels of heterogeneous nuclear RNAs (hnRNA). Through splicing, these hnRNAs are processed into 3 or more mature APP RNAs. The amounts of each of these similar but nonidentical APP RNAs may yield ratios of APP proteins which are required for neuronal survival, pathogenesis of neurons and/or produce phenocopies of learning and memory mutants of Drosophila.

          Related collections

          Author and article information

          Journal
          Neurobiol. Aging
          Neurobiology of aging
          0197-4580
          0197-4580
          : 10
          : 5
          Affiliations
          [1 ] Medical Research Division, Lederle Laboratories, American Cyanamid Company, Pearl River, NY 10965.
          2510042

          Comments

          Comment on this article