Artificial dermal substitutes for tissue regeneration: comparison of the clinical outcomes and histological findings of two templates

Abstract

Objective

Artificial dermal substitutes (DSs) are fundamental in physiological wound healing to ensure consistent and enduring wound closure and provide a suitable scaffold to repair tissue. We compared the clinical and histological features of two DSs, Pelnac and Integra, in the treatment of traumatic and iatrogenic skin defects.

Methods

This prospective observational study involved 71 randomly selected patients from our hospital. Wound healing was analyzed using the Wound Surface Area Assessment, the Vancouver Scar Scale, and a visual analog scale. Histological and immunohistochemical evaluations were also performed.

Results

At 2 weeks, greater regeneration with respect to proliferation of the epidermis and renewal of the dermis was observed with Pelnac than with Integra. At 4 weeks, the dermis had regenerated with both DSs. Both templates induced renewed collagen and revascularization. Differences in the Vancouver Scar Scale score were statistically significant at 4 weeks and 1 year. Pelnac produced a significant increase in contraction at 2 weeks with increasing effectiveness at 4 weeks. Integra produced a higher percentage reduction in the wound surface area and a shorter healing time than Pelnac for wounds >1.5 cm deep.

Conclusion

Our observational data indicate that both DSs are effective and applicable in different clinical contexts.

Journal

Journal ID (nlm-ta): J Int Med Res

Journal ID (iso-abbrev): J. Int. Med. Res

Journal ID (publisher-id): IMR

Journal ID (hwp): spimr

Title: The Journal of International Medical Research

Publisher: SAGE Publications (Sage UK: London, England )

ISSN (Print): 0300-0605

ISSN (Electronic): 1473-2300

Publication date (Electronic): 13 August 2020

Publication date Collection: August 2020

Volume: 48

Issue: 8

Affiliations

[1 ]Department of Reconstructive Surgery and Hand Surgery, AOU “Ospedali Riuniti”, Ancona, Italy

[2 ]Accademia del Lipofilling, Research and Training Center in Regenerative Surgery, Montelabbate (PU), Italy

[3 ]Department of Neuroscience, Biomedicine and Movement, Human Anatomy and Histology Section, University of Verona, Verona, Italy

[4 ]Clinic of Plastic and Reconstructive Surgery, Department of Medical Area (DAME), University of Udine, Italy

[5 ]Department of Plastic and Reconstructive Surgery, IRCCS Policlinico San Donato, University of Milan, Milan, Italy

[6 ]Data Analysis Office, University of Milan, Milano, Italy

[7 ]School of Biosciences and Veterinary Medicine, University of Camerino, Matelica, MC, Italy

Author notes

Francesco De Francesco, Department of Reconstructive Surgery and Hand Surgery, AOU “Ospedali Riuniti,” via Conca 71, Ancona 60123, Italy. Emails: fran.defr@ 123456libero.it ; francesco.defrancesco@ 123456ospedaliriuniti.marche.it

Article

Publisher ID: 10.1177_0300060520945508

DOI: 10.1177/0300060520945508

PMC ID: 7427157

PubMed ID: 32790486

Copyright statement: © The Author(s) 2020

License:

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

Categories

Subject: Prospective Clinical Research Report

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