Francesco De Francesco 1 , 2 , Alice Busato 3 , Silvia Mannucci 3 , Nicola Zingaretti 2 , 4 , Giuseppe Cottone 5 , Francesco Amendola 5 , Marialuisa De Francesco 6 , Flavia Merigo 3 , Valentina Riccio 7 , Luca Vaienti 2 , 5 , Pier Camillo Parodi 2 , 4 , Andrea Sbarbati 2 , 3 , Michele Riccio 1 , 2
13 August 2020
Artificial dermal substitutes (DSs) are fundamental in physiological wound healing to ensure consistent and enduring wound closure and provide a suitable scaffold to repair tissue. We compared the clinical and histological features of two DSs, Pelnac and Integra, in the treatment of traumatic and iatrogenic skin defects.
This prospective observational study involved 71 randomly selected patients from our hospital. Wound healing was analyzed using the Wound Surface Area Assessment, the Vancouver Scar Scale, and a visual analog scale. Histological and immunohistochemical evaluations were also performed.
At 2 weeks, greater regeneration with respect to proliferation of the epidermis and renewal of the dermis was observed with Pelnac than with Integra. At 4 weeks, the dermis had regenerated with both DSs. Both templates induced renewed collagen and revascularization. Differences in the Vancouver Scar Scale score were statistically significant at 4 weeks and 1 year. Pelnac produced a significant increase in contraction at 2 weeks with increasing effectiveness at 4 weeks. Integra produced a higher percentage reduction in the wound surface area and a shorter healing time than Pelnac for wounds >1.5 cm deep.