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Effect of co-trimoxazole prophylaxis on morbidity, mortality, CD4-cell count, and viral load in HIV infection in rural Uganda.
Jonathan Mermin
1 ,
John Lule ,
John Paul Ekwaru ,
Samuel Malamba ,
Robert Downing ,
Ray Ransom ,
Frank Kaharuza ,
David Culver ,
Francis Kizito ,
Rebecca Bunnell ,
Aminah Kigozi ,
Damalie Nakanjako ,
Winnie Wafula ,
Robert Quick
October 19 2004
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Abstract
Prophylaxis with co-trimoxazole (trimethoprim-sulphamethoxazole) is recommended for people with HIV infection or AIDS but is rarely used in Africa. We assessed the effect of such prophylaxis on morbidity, mortality, CD4-cell count, and viral load among people with HIV infection living in rural Uganda, an area with high rates of bacterial resistance to co-trimoxazole.