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      General mechanisms of metastasis

      Author(s): , ,
      Publication date Created:
      Publication date (Print):
      Journal: Cancer
      Publisher: Wiley

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          Abstract

          In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), and cell proliferation. Molecular mechanisms underlying each of these steps are described. Based on blocking these processes, new anti-metastasis therapies are being developed.

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          Most cited references81

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          Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.

          M O'Reilly, L Holmgren, Y Shing … (1994)
          The phenomenon of inhibition of tumor growth by tumor mass has been repeatedly studied, but without elucidation of a satisfactory mechanism. In our animal model, a primary tumor inhibits its remote metastases. After tumor removal, metastases neovascularize and grow. When the primary tumor is present, metastatic growth is suppressed by a circulating angiogenesis inhibitor. Serum and urine from tumor-bearing mice, but not from controls, specifically inhibit endothelial cell proliferation. The activity copurifies with a 38 kDa plasminogen fragment that we have sequenced and named angiostatin. A corresponding fragment of human plasminogen has similar activity. Systemic administration of angiostatin, but not intact plasminogen, potently blocks neovascularization and growth of metastases. We here show that the inhibition of metastases by a primary mouse tumor is mediated, at least in part, by angiostatin.
          Article 0 comments Cited 377 times – based on 0 reviews     Review now
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            Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation.

            Lance Liotta, Patricia S Steeg, William Stetler-Stevenson (1991)
            Article 0 comments Cited 264 times – based on 0 reviews     Review now
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              Integrins: Versatility, modulation, and signaling in cell adhesion

              Richard O. Hynes (1992)
              Cell, 69(1), 11-25
              Article 0 comments Cited 216 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: Cancer
                Abbreviated Title: Cancer
                Publisher: Wiley
                ISSN (Print): 0008-543X
                ISSN (Electronic): 1097-0142
                Publication date Created: October 15 1997
                Publication date (Print): October 15 1997
                Volume: 80
                Issue: S8
                Pages: 1529-1537
                Article
                DOI: 10.1002/(SICI)1097-0142(19971015)80:8+<1529::AID-CNCR2>3.0.CO;2-F
                PubMed ID: 9362419
                SO-VID: 1e42beef-01c4-46cb-9dfe-571fd5aef84b
                Copyright © © 1997
                License:

                http://doi.wiley.com/10.1002/tdm_license_1.1

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