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      General mechanisms of metastasis.

      Lancet

      Bone Neoplasms, secondary, Cell Adhesion, Cell Adhesion Molecules, physiology, Growth Substances, metabolism, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, pathology, Neovascularization, Pathologic, Tissue Inhibitor of Metalloproteinases

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          Abstract

          In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), and cell proliferation. Molecular mechanisms underlying each of these steps are described. Based on blocking these processes, new anti-metastasis therapies are being developed.

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          9362419

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