Takuto Miyamura 1 , Noriho Sakamoto , 1 , Tomoyuki Kakugawa 1 , Daisuke Okuno 1 , Hirokazu Yura 1 , Shota Nakashima 1 , Hiroshi Ishimoto 1 , Takashi Kido 1 , Daisuke Taniguchi 2 , Takuro Miyazaki 2 , Tomoshi Tsuchiya 2 , Shin Tsutsui 4 , Hiroyuki Yamaguchi 1 , Yasushi Obase 1 , Yuji Ishimatsu 3 , Kazuto Ashizawa 4 , Takeshi Nagayasu 2 , Hiroshi Mukae 1
15 July 2019
Acute exacerbation of interstitial pneumonia (AE-IP) is a serious complication of pulmonary surgery in patients with IP. However, little is known about AE-IP after non-pulmonary surgery. The aim of this study was to determine the frequency of AE-IP after non-pulmonary surgery and identify its risk factors.
One hundred and fifty-one patients with IP who underwent pulmonary surgery and 291 who underwent non-pulmonary surgery were retrospectively investigated.
AE-IP developed in 5 (3.3%) of the 151 patients in the pulmonary surgery group and 4 (1.4%) of the 291 in the non-pulmonary surgery group; the difference was not statistically significant. A logistic regression model showed that serum C-reactive protein (CRP) was a predictor of AE-IP in the non-pulmonary surgery group (odds ratio 1.187, 95% confidence interval 1.073–1.344, P = 0.002).
This is the first study to compare the frequency of AE-IP after pulmonary surgery with that after non-pulmonary surgery performed under the same conditions. The results suggest that the frequency of AE-IP after non-pulmonary surgery is similar to that after pulmonary surgery. A high preoperative C-reactive protein level is a potential risk factor for AE-IP after non-pulmonary surgery.