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      Growth Hormone Treatment in Patients with Neurosecretory Dysfunction

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          Abstract

          Twenty-four children (14 boys and 10 girls) with neurosecretory dysfunction, defined by a response > 10 ng/ml to two pharmacological tests, and 24-hour GH secretion < 3 ng/ml/min, were treated with biosynthetic hGH. Mean age was 10 years 8 months ± 3 years 6 months. Growth retardation was -2.8 ± 0.8 SD. Eighteen children were prepubertal and six pubertal (P2). Mean peaks in two pharmacological stimulation tests were 25.8 ± 14.8 and 20.8 ± 11.5 ng/ml. Somatomedin C/insulin-like growth factor I level was 0.8 ± 0.6 IU/ml in the prepubertal children. Twenty-four-hour integrated concentration of GH was low, at 2.2 ± 0.5 ng/ml/min. Analysis of secretory profiles showed 3 types: (1) hyperpulsatile profile with numerous peaks of low amplitude, (2) flat profile, (3) profile with an isolated peak > 10 ng/ml. Treatment with hGH (0.42 IU/kg/week) resulted in an increase in growth velocity from 4.9 ± 1.2 to 6.8 ± 2.2 cm/year. These results are comparable to those of a group with total GH deficiency receiving the same dose. Analysis of the results showed a group of good responders (n = 14, growth velocity: 8.1 cm/year) and a group of poor responders (n = 10, growth velocity: 4.9 cm/year). Thus, treatment of neurosecretory dysfunction with hGH gives results comparable to those obtained in classic GH secretory dysfunction.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-5290-5
          978-3-318-01979-7
          1663-2818
          1663-2826
          1990
          1990
          02 December 2008
          : 33
          : Suppl 4
          : 97-101
          Affiliations
          Services de Pédiatrie (Unité d’Endocrinologie) et d’Exploration Neurologique, CHU Rangueil, Toulouse, France
          Article
          181592 Horm Res 1990;33:97–101
          10.1159/000181592
          2245976
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          The Seville hGH Symposium

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