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      Decrease in CD4+CD25+FoxP3+ Treg cells after pulmonary resection in the treatment of cavity multidrug-resistant tuberculosis.

      International Journal of Infectious Diseases
      Adolescent, Adult, Aged, Antigens, CD4, metabolism, Female, Flow Cytometry, Forkhead Transcription Factors, Humans, Interleukin-2 Receptor alpha Subunit, Lung, immunology, radiography, surgery, Male, Middle Aged, Mycobacterium tuberculosis, Pneumonectomy, methods, T-Lymphocytes, Regulatory, cytology, Tomography Scanners, X-Ray Computed, Tuberculosis, Multidrug-Resistant, microbiology, Tuberculosis, Pulmonary, Young Adult

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          Abstract

          Immune regulatory mechanisms may limit the immunopathologic condition of infection with Mycobacterium tuberculosis and suppress cellular immune responses in the host. We investigated the CD4(+)CD25(+)FoxP3(+) circulating regulatory T cells (T(reg)) in patients with cavity multidrug-resistant tuberculosis (MDR-TB) before and after surgery. We compared the proportion of T(reg) cells in 13 patients with cavity MDR-TB pre- and postoperatively and in 10 healthy control subjects by flow cytometry using three specific markers in peripheral blood lymphocytes: cell-surface CD4 and CD25 expression and intracellular FoxP3 expression. The proportion of CD4(+)CD25(high) and CD4(+)CD25(+)FoxP3(+) T(reg) was significantly higher in patients with cavity MDR-TB and at 1-month postoperatively than in healthy controls (p<0.001). The proportion of CD4(+) and CD4(+)CD25(-) cells was significantly lower in patients with cavity MDR-TB than in controls (p<0.001). Pre- and postoperative proportions of CD4(+)CD25(high) and CD4(+)CD25(+)FoxP3(+) T(reg) cells showed a positive correlation (r=0.878, p<0.001). Circulating T(reg) cells are increased in proportion in patients with cavity MDR-TB and decreased after surgery. Infection with M. tuberculosis may induce T(reg) cell-surface molecular changes with increased numbers of cells. Copyright © 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

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