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      Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation.

      Eukaryotic Cell
      5-Methylcytosine, analysis, Animals, Cryptosporidium parvum, genetics, DNA Methylation, DNA, Protozoan, metabolism, Mass Spectrometry, Toxoplasma

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          Abstract

          Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.

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          Author and article information

          Journal
          18178772
          2268521
          10.1128/EC.00448-07

          Chemistry
          5-Methylcytosine,analysis,Animals,Cryptosporidium parvum,genetics,DNA Methylation,DNA, Protozoan,metabolism,Mass Spectrometry,Toxoplasma

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