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      DLS and zeta potential - What they are and what they are not?

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          Abstract

          Adequate characterization of NPs (nanoparticles) is of paramount importance to develop well defined nanoformulations of therapeutic relevance. Determination of particle size and surface charge of NPs are indispensable for proper characterization of NPs. DLS (dynamic light scattering) and ZP (zeta potential) measurements have gained popularity as simple, easy and reproducible tools to ascertain particle size and surface charge. Unfortunately, on practical grounds plenty of challenges exist regarding these two techniques including inadequate understanding of the operating principles and dealing with critical issues like sample preparation and interpretation of the data. As both DLS and ZP have emerged from the realms of physical colloid chemistry - it is difficult for researchers engaged in nanomedicine research to master these two techniques. Additionally, there is little literature available in drug delivery research which offers a simple, concise account on these techniques. This review tries to address this issue while providing the fundamental principles of these techniques, summarizing the core mathematical principles and offering practical guidelines on tackling commonly encountered problems while running DLS and ZP measurements. Finally, the review tries to analyze the relevance of these two techniques from translatory perspective.

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          Author and article information

          Journal
          J Control Release
          Journal of controlled release : official journal of the Controlled Release Society
          Elsevier BV
          1873-4995
          0168-3659
          Aug 10 2016
          : 235
          Affiliations
          [1 ] School of Veterinary Medicine, University College Dublin (UCD), Belfield, Dublin 4, Ireland. Electronic address: sourav.bhattacharjee@ucd.ie.
          Article
          S0168-3659(16)30383-2
          10.1016/j.jconrel.2016.06.017
          27297779
          1e682572-d3b2-4cc4-a765-b664a20a5773

          Colloid stability,DLS,Hydrodynamic radius,Surface charge,Surface potential,Zeta potential

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