Postinfarction Metoprolol Treatment: Effects on Prognosis in Relation to Serum Cholesterol Concentrations

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Abstract

In a double-blind randomized study of 154 postmyocardial infarction patients assigned to metoprolol (100 mg twice daily) and 147 patients assigned placebo, the outcome during a 3-year follow-up according to serum cholesterol concentrations was evaluated. There was no indication that metoprolol influenced the total serum cholesterol concentration. The median cholesterol value at 3 months was 6.7 mmol/l. In patients with cholesterol >6.7 mmol/l, nonfatal reinfarctions were reduced in the metoprolol group (7 vs. 24%; p < 0.01). In patients with cholesterol > 6.7 mmol/l, mortality was lower in those treated with metoprolol (8 vs. 20%; p < 0.05). The beneficial effect of conventional postinfarction beta-blockade with metoprolol is independent of serum cholesterol concentration.

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Author and article information

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1987

Publication date (Print): 1987

Publication date (Electronic): 11 November 2008

Volume: 74

Issue: 6

Pages: 457-464

Affiliations

Department of Medicine, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden

Article

Publisher ID: 174238 Other ID: Cardiology 1987;74:457–464

DOI: 10.1159/000174238

PubMed ID: 3435909

SO-VID: 1e684c19-6a95-42af-9aef-f83304e7ef4a

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 21 July 1986

Date accepted : 25 December 1986

Page count

Pages: 8

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