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      Vascular tissue engineering.

      Annual review of biomedical engineering

      Prosthesis Design, Muscle, Smooth, Vascular, Humans, Endothelium, Vascular, transplantation, Blood Vessels, trends, methods, Biomedical Engineering, Biocompatible Materials, Animals

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          Abstract

          The development of a tissue-engineered blood vessel substitute has motivated much of the research in the area of cardiovascular tissue engineering over the past 20 years. Several methodologies have emerged for constructing blood vessel replacements with biological functionality. These include cell-seeded collagen gels, cell-seeded biodegradable synthetic polymer scaffolds, cell self-assembly, and acellular techniques. This review details the most recent developments, with a focus on core technologies and construct development. Specific examples are discussed to illustrate both the benefits and shortcomings of each methodology, as well as to underline common themes. Finally, a brief perspective on challenges for the future is presented.

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          Journal
          10.1146/annurev.bioeng.3.1.225
          11447063

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