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Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial.
Ralf-Dieter Hofheinz
1 ,
Frederik Wenz ,
Stefan Post ,
Axel Matzdorff ,
Stephan Laechelt ,
Jörg T Hartmann ,
Lothar Müller ,
Hartmut Link ,
Markus Moehler ,
Erika Kettner ,
Elisabeth Fritz ,
Udo Hieber ,
Hans Walter Lindemann ,
Martina Grunewald ,
Stephan Kremers ,
Christian Constantin ,
Matthias Hipp ,
Gernot Hartung ,
Deniz Gencer ,
Peter Kienle ,
Iris Burkholder ,
Andreas Hochhaus
Jun 2012
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Abstract
Fluorouracil-based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. We investigated the efficacy and safety of substituting fluorouracil with the oral prodrug capecitabine.